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| Section | Objectives |
|---|---|
| Topic 1: Clinical Trial Operations | - Study start-up activities
|
| Topic 2: Data Management and Documentation | - Clinical trial documentation
|
| Topic 3: Ethical and Participant Safety Considerations | - Regulatory compliance
|
| Topic 4: Professional Responsibilities | - Leadership and professionalism
|
| Topic 5: Quality Management | - Risk management
|
1. Per the protocol, participants' blood creatinine level must be no greater than 2.5 times the upper limit of normal (0.7-1.2 mg/dL). What is the maximum creatinine level the participant can have and be eligible for the trial?
A) 2.6 mg/dL
B) 3.6 mg/dL
C) 1.8 mg/dL
D) 3.0 mg/dL
2. Which of the following reports should be retained in participant charts?
A) DSMB/IDMC reports
B) Safety reports
C) Lab reports
D) IRB/IEC progress reports
3. One key attribute for good study documentation is that the data are contemporaneous, which refers to the practice of:
A) Recording data on source documents at the time the data are collected during the conduct of the study.
B) Recording the date and time each data element is entered onto the source document.
C) Comparing source document data to other data recorded in the same study time period.
D) Allowing real-time access for data review in the eCRF.
4. A protocol amendment is needed to collect additional data from a participant's medical record. When can the research team begin collecting the additional data?
A) As soon as the protocol amendment is submitted to the IRB/IEC
B) After the original planned data collection is completed
C) After the protocol amendment is approved by the IRB/IEC
D) When the need for the additional data is discovered
5. A written description of a trial in which the clinical and statistical description, presentations, and analyses are fully integrated into a single document is called a:
A) Clinical Study Report
B) IDMC/DSMB Report
C) Investigator Brochure
D) Clinical Study Protocol
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: C | Question # 3 Answer: A | Question # 4 Answer: C | Question # 5 Answer: A |
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